Potassium-sparing diuretics (amiloride, triamterene, spironolactone, and eplerenone) are active in the distal tubule and inhibit the exchange of sodium for potassium. Is Metolazone potassium sparing? valsartan increases and metolazone decreases serum potassium. Metaxalone, a muscle relaxant, is a medicine with a similar name.. Metolazone is a thiazide diuretic marketed under the brand names Zaroxolyn and Mykrox.It is primarily used to treat congestive heart failure and high blood pressure. PDF Rx Only DO NOT INTERCHANGE DO NOT INTERCHANGE METOLAZONE TABLETS, USP ... Farmakokinetik Metolazone hanya tersedia dalam lisan persiapan. The most potent diuretics are the loop diuretics, followed by mannitol, metolazone (a thiazide-like diuretic), the thiazides, and the potassium-sparing diuretics The potency of diuretics is a function of where they work in the nephron to inhibit sodium and water resorption. (See . Metolazone (Amici Pharmaceuticals LLC.): FDA Package Insert delivery of sodium to the distal tubular exchange site results in increased potassium excretion. The additional blood pressure (BP)-lowering effect provided by the addition of a PS diuretic is unclear. Metolazone Tablets are a diuretic indicated for the treatment of salt and water retention including edema accompanying congestive heart failure, and edema accompanying renal diseases, including the nephrotic syndrome and states of diminished renal function.Metolazone tablets are also indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs of a . However, potassium-sparing diuretics are weak diuretics when used alone and thus should never be used as sole agents in animals with heart failure. Diuresis with subsequent . (Dyrenium) -Potassium sparing diuretic. They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. Amiloride and triamterene inhibit potassium secretion directly and thus can help maintain .